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Core Facilities

Developmental Core - Core B
In keeping with the mission of the CFAR, the Developmental Core aims:

  • to strengthen and enhance the scientific productivity of the CFAR via feasibility study/pilot project awards
  • to encourage collaboration and enable a rapid response to emerging opportunities in AIDS research
  • to develop new technologies that will expedite the AIDS research

Clinical Core - Core C

  • Biostatistics and Epidemiology
    The CFAR Biostatistics and Epidemiology Core provides a variety of services to encourage the rapid conduct of patient-based research. These services include epidemiological and biostatistical consultation, biomathematical modeling, and data management.
  • Specimen Management
    The CFAR Specimen Management Core provides - processing and storage of biological samples from HIV-infected patients and uninfected controls - cataloging and distribution of information on stored specimens and - procurement of fresh biological samples for HIV/AIDS studies.

Flow Cytometry Core - Core D
The CFAR Flow Cytometry Core provides an array of innovative flow measurements in addition to the usual 3-color surface phenotyping of lymphocytes. Its staff is available for training and consultation on these methods.

Immunology Core - Core E
The CFAR Immunology Core Facility provides - A range of immunologic assays - Testing of polyclonal sera as well as human, primate and rodent anti-HIV mAbs for neutralizing activity against a wide range of HIV primary isolates and for their ability to bind to intact virions and to infected cells. - Provision of human anti-HIV mAbs. Frozen stocks of more than 70 mycoplasma-free cell lines producing human anti-HIV mAbs are maintained in the Core.

Virology Core - Core F
The CFAR Virology Core consists of 3 units. One concentrates on bulk and quantitative HIV culture, measurement, resistance testing, phenotype analysis , and genotype analysis using the heteroduplex mobility assay and sequencing. The second quantitates HIV RNA in plasma or culture fluids by the Roche RT-PCR method. The third is a standard, licensed virology lab which detects the presence of herpes viruses (HSV, CMV, HHV6, VZV, and EBV) by culture and/or PCR, as well as other viruses such as HCV and JC by PCR.